Bioinformatics: a practical guide to the analysis of genes and proteins (2nd ed. 2001)

Providing biologists with the modern tools to solve practical problems in sequence data analysis and management, this completely revised and updated edition offers a review of the basic concepts, along with discussions and comparisons of the available databases and computational analysis tools relevant to biological research. l Spans the broad spectrum of topics in bioinformatics, from Internet use to predictive algorithms, without requiring advanced mathematics or computer science literacy l Covers important concepts and state-of-the-art tools Includes new chapters on comparative genomics, large-scale genome analysis, sequence assembly, and expressed sequence tags l Problem sets are included at the end of each chapter with an accompanying web site for answers, links, and updates l Includes glossary, appendices, and end-of-the-chapter bibliographies

Bioinformatics and the Internet. The NCBI data model. The GenBank sequence database. Submitting DNA sequences to the databases. Structure databases. Genomic mapping and mapping databases. Information retrieval from biological. Sequence alignment and database searching. Multiple sequence alignment. Predictive methods using DNA sequences. Predictive methods using protein sequences. Expressed sequence tags (ESTs). Sequence assembly and finishing methods. Phylogenetic analysis. Comparative genome analysis. Large-scale genome analysis. Using Perl to facilitate biological analysis.