Essentials of apoptosis: a guide for basic and clinical research

This work summarizes the concepts, molecular architecture, biochemical pathways, and pathophysiological significance of apoptosis, and describes standard biochemical and cell biologic approaches to apoptosis research as a guideline for bench work, with clinical applications detailed for immune disor

Part I: Molecules and Pathways of ApoptosisCaspases: Structur. Activation Pathway. and SubstratesBrona M. Murphy and Seamus J. MartinBcl-2 Family Proteins: Master Regulators of ApoptosisXiao-Ming Yi. Wen-Xing Din. and Yongge ZhaoInhibitors of Apoptosis ProteinsPeter Listo. Wai Gin Fon. and Robert G. KornelukStructural Biology of Programmed Cell DeathYigong ShiThe Death Receptor Family and the Extrinsic PathwayMaria Eugenia Guicciardi and Gregory J. GoresThe Mitochondrial Apoptosis PathwayBruno AntonssonFrom Caspases to Alternative Cell-Death MechanismsMarja Jäättelä and Marcel LeistPart II: Apoptosis in ActionApoptosis in Plant. Yeas. and BacteriaRon Mittler and Vladimir ShulaevProgrammed Cell Death in C. elegansYi-Chun Wu and Ding XueCell Death in DrosophilaSujin Bao and Ross L. CaganCell Death in Mammalian DevelopmentChia-Yi Kuan and Keisuke KuidaApoptosis and Cancer: Pathogenic and Therapeutic ImplicationsSean L. O'Conno. Fermin Brione. Nikhil S. Char. Song H. Ch. Rebecca L. Ham. Yoshihiko Kadowak. Sangjun Le. Kevin B. Spurger. and Timothy J. McDonnellCell Death in Immun. Inflammator. and Stress ResponsesJ. John Cohe. Maria D. Devor. Mile Cikar. and Elizabeth A. DowlingCell-Death Mechanisms in Neurodegenerative Diseases: Diversity Among Cerebral Ischemi. Parkinson's Diseas. and Huntington's DiseaseR. Anne Stetler and Jun ChenApoptosis in Ischemic DiseaseZheng Dong and Manjeri A. VenkatachalamPart III: Approaches to the Study of ApoptosisAnalysis of Apoptosis: Basic Principles and ProceduresLi Ba. Jinzhao Wan. Xiao-Ming Yi. and Zheng DongIndex