Capute and Accardo's Neurodevelopmental Disabilities in Infancy and Childhood (4^th Ed.)

Capute and Accardo?s Neurodevelopmental Disabilities in Infancy and Childhood, Fourth Edition provides updated foundational, theoretical, and practical knowledge on the spectrum and continuum of neurodevelopmental disabilities shaped by ongoing advances in neuroscience and related disciplines. It reviews the over-arching principles of assessment, diagnosis, and management of patients with a wide range of neurodevelopmental disabilities. Streamlined or fully rewritten chapters, including developmental screening and surveillance, neuroimaging and genetic evaluation, early intervention, principles of pharmacological treatment, principles of successful management programs, aging and transition planning, telemedicine and care in low-resource settings are included.

The book's practical, expert-led approach aims to prepare future clinicians to skillfully assess and manage children with neurodevelopmental disabilities with the aid of clinical approach flowcharts to common presentations, diagnostic algorithms and clinic notes templates.

Section 1. Spectrum of Developmental Disabilities
1. Definition and conceptualization
2. Typical neurodevelopment
3. What causes NDD?
4. Themes from the neuroscience of NDD
5. Clinical phenotypes of NDD: definition and examples (DSMV or ICD-10)
6. Risk/Screening and Early identification

Section 2. Diagnostic Processes
7. History and physical examination
8. Neurodevelopmental examination (age specific, standardized tools, value of serial evaluations, developmental curves, the 3 Ds: delay, dissociation and deviance)
9. Clinical formulationsi

Section 3. Etiologic Evaluation (indications, advantages, disadvantages, utility, methods, interpretation)
10. Neuroimaging: (Fetal MRI, Head US, brain MRI: structural, functional, metabolic, connectomics)
11. Genetic evaluation (karyotyping, SNP and next generation sequencing)
12. Electrophysiology
13. Neuropsychology and education
14. PT/OT
15. Speech and Language
16. Vision and hearing evaluation
17. Family functioning / social
18. Continuum of NDD expression – comorbidities and differential diagnosis

Section 4. NDD beyond the diagnosis: Management/Therapy
19. Prevention (primary, secondary and tertiary)
20. Early intervention (Utility and Futility)
21. Management vs Therapy: (intensity, duration, success, failure, costs, utility and futility)
22. Specific therapiesi
23. The medical home and interdisciplinary care
24. Community support and advocacy
25. Telemedicine
26. Management/therapy in low resource settings
27. Preparing for the many transitionsi

Section 5. Future Directionsi. Research in NDD
28. Limitations and challenges
29. From observation to intervention

Dr. Fatima Ismail is an assistant professor of paediatric neurology and developmental medicine at the College of Medicine and Health Sciences, UAE University and an adjunct assistant professor of neurology at Johns Hopkins School of Medicine. She received her Bachelor of medicine and Bachelor of surgery (M.B.B.S.) degree from UAE University, completed paediatric residency training at the Harriet Lane program at Johns Hopkins Hospital, and advanced training in the Johns Hopkins/Kennedy Krieger conjoint residency in Paediatric Neurology and Neurodevelopmental Disabilities. Dr. Ismail is a diplomate of the American Board of Paediatrics. She is a member of the American Academy of Neurology (AAN), the Child Neurology Society (CNS), the American Neurological Association (ANA) and the International Child Neurology Association (ICNA). Her clinical interest is in improving the neurodevelopmental outcomes of children with acute brain injury (stroke and traumatic brain injury) by implementing brain protective measures and protocols in the neonatal and paediatric intensive care units, and establishing a comprehensive multidisciplinary neuroplasticity-informed neurodevelopmental follow-up programs. Her research focus is on understanding changes in structural, functional and effective connectivity in the developing brain as a function of maturation and following injury using non-invasive brain stimulation (transcranial magnetic stimulation/transcranial direct current stimulation) coupled with EEG and advanced neuroimaging techniques (diffusion tensor imaging and functional MRI).
Dr. Pasquale Accardo is Professor of Pediatrics at Virginia Commonwealth University in Richmond. He received his medical degree from Downstate Medical Center, Brooklyn, New York; completed his pediatric residency at James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, and obtained his developmental pediatrics training at the John F. Kennedy Institute for Han