Modeling in biopharmaceutics, pharmacoki netics & pharmacodynamics : Homogeneous & heterogeneous approaches, (Interdiscip linary applied mathematics, Vol. 30)

The subject of Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics is the state of the art of modeling approaches in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics (BPP). The book discusses ways in which classical and non-classical mathematical models may be used to describe drug processes and therapeutic effect in the human body. It is divided into four parts, the first dealing with the fundamental principles of fractals, diffusion and nonlinear dynamics, the second with drug dissolution, release and absorption, the third with empirical, compartmental and stochastic pharmacokinetic models, and the fourth with classical and non-classical aspects of pharmacodynamics. The book is intended to introduce the concepts of fractals, anomalous diffusion and the associated non classical kinetics, and stochastic modeling, within nonlinear dynamics and illuminate with their use the intrinsic complexity of drug processes in homogeneous and heterogeneous media. In parallel fashion, the book also covers all classical models that have direct relevance and application to the biopharmaceutics, pharmacokinetics and pharmacodynamics. This timely and useful book will appeal to researchers and graduate students in pharmacology, pharmaceutical sciences, physiology, applied mathematics, and biomathematical statistics.

From the reviews:"This book presents a novel modelling approach to biopharamceutics, pharmacokinetics and pharmacodynamic phenomena. ... This state-of-the-art volume will be helpful to students and researchers in pharmacology, bioengineering, and physiology. This book is a must for pharmaceutical researchers to keep up with recent developments in this field." (P. R. Parthasarathy, Zentralblatt MATH, Vol. 1103 (5), 2007)