Covid-19 Metabolomics and Diagnosis, 1st ed. 2023 Volume 2

This book presents a collection of chapters on Covid-19 topics, with focus on the metabolomics and diagnosis. The chapters report on diagnostic tests for detection of SARC-CoV-2 virus and related proteins as well as post-Covid omics. This book covers Fourier-Transform Infrared spectroscopy and spectromicroscopy applied to Covid-19 studies and Carbon Nanomaterials as Covid-19 Electrochemical sensors. Moreover, the reader will find content on 3D printing for virus diagnosis, as well as organ-on-a-chip models for viral infection proteomics interaction.

Fourier-Transform Infrared Spectroscopy and Spectromicroscopy Applied to Covid-19 Studies.- Point-of-Care Devices with Electrochemical Detection For Covid-19 Diagnosis.- Carbon Nanomaterials for Covid-19 Electrochemical Sensors.- Use of Metallic Nanostructures In Electrochemical Biosensing of Sars-Cov-2.- 3d Printing For Virus Diagnosis.- Post-Covid-19 Metabolomics: Pursuing the Sequels af a Pandemic.- Metabolic Behavior of Covid-19 Infection Severity.- “Pandemics-On-A-Chip”: Organ-On-A-Chip Models for Studying Viral Infections.

Frank N. Crespilho is Professor of Physical-Chemistry at Chemistry Institute of University of Sao Paulo, São Carlos since 2012. He was Associate Professor of Chemistry at Federal University (UFABC), Brazil (2009-2012), Visiting Associate in Chemistry at California Institute of Technology, Caltech (EUA), and Visiting Professor at Max-Planck-Institute for Solid State Research, Stuttgart, Germany (2016). He was Visiting Professor at Harvard University (2018-2019) and since 2019 he is Fellow of the J. A. P. School of Engineering and Applied Sciences, Harvard University at the lab of Prof. Michael Aziz. He is the Coordinator of COVID-19 Network in metabolomics and diagnostics chemistry at the University of São Paulo. He was one of the inventors of the "Popular Fast Test of COVID-19", costing less than a dollar, for mass testing in developing countries. His research interests include fundamental and applied bioelectrochemistry with a distinctive focus on the chemistry of energy, life and health. His work combines physical chemical methods and instrumentation development timely application to biological fuel cells and bioinspired batteries, biosensors technology and electron transfer reactions in biological system. His recent work focuses on in situ and operando spectroscopic-electrochemistry elucidation of the electron transfer mechanism involving redox enzyme, proteins, DNA, and drug delivery in single cells. He has made contributions on the field of protein immobilization processes on solid surfaces, single cells micro-FTIR analysis, bio-electrocatalysis and coupling analytical tools to resolve electron transfer mechanism in proteins. Dr. Crespilho developed a technique named Electrochemical Coupled Vibrational Spectromicroscopy (EVSM), which consist in a multiplex infrared spectroscopy imaging system for monitoring spatially resolved redox chemistry in bioelectrodes, bioinorganic molecules, biological films and single cells.