Domains i integrins

In vertebrates, the integrin family includes 24 members. As the ?-chains were sequenced, some were observed to have an inserted domain similar to the A domain in several matrix and complement proteins. This inserted ligand binding domain is interactive and was called the I domain in integrins. More recently structural data have shown that an integrin ?-chain also contains an I domain. Nine of the currently known 18 ?-chains contain an I domain. This book systematically goes through the current knowledge about these integrins, including the newest additions to the integrin family, the collagen-binding ?10?1 and ?11?1 integrins. The book discusses ligand binding, signalling properties, knock-out phenotypes and possible involvement in disease. This book comprehensively reviews the current knowledge about I domains in integrins and will serve as a useful reference book for scientists in this field.

Preface. 1. Evolution of Integrin I-Domains, M.S. Johnson, D. Tuckwell. 2. Integrin alpha1beta1, H. Gardner. 3. Function of alpha2beta1 Integrin, M.M. Zutter, S.A. Santoro. 4. Structure Distribution and Function of alpha10beta1 Integrin, E. Lundgren-Åkerlund, M. Schneller. 5. Structure and Function of alpha11beta1 Integrin, D. Gullberg, S.N. Popova, C.-F. Tiger. 6. Structure and Activation of beta2-Integrins, C.G. Gahmberg, S. Fagerholm. 7. Integrin alphaEbeta7: Molecular Features and Functional Significance in the Immune System, P.J. Kilshaw, J.M.G. Higgins. 8. Structural Aspects of Integrins, R.C. Liddington. 9. Integrin Recognition Motifs in Collagens, R.W. Farndale. 10. Cellular Signaling by Collagen-Binding Integrins, J. Heino. 11. Collagen-Binding Integrins and Disease, B. Eckes, B. Nieswandt, T. Krieg. 12. Integrins in Immune and Inflammatory Disease, A.R. de Fougerolles. Index.